Recombinant Human Homeobox protein prophet of Pit-1 (PROP1)

Uniprot Id

O75360

Target Species

Human

Target Name

PROP1

Target Full Name

Homeobox protein prophet of Pit-1

Target Function

Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Target Involvement

Pituitary hormone deficiency, combined, 2 (CPHD2)

Target Subcellular Location

Nucleus.

Target Protein Families

Paired homeobox family

Target Tissue Specificity

Expressed specifically in embryonic pituitary.

Target Synonyms

PROP1; Homeobox protein prophet of Pit-1; PROP-1; Pituitary-specific homeodomain factor

Target Background

This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.