Recombinant Human Inosine-5′-monophosphate dehydrogenase 2 (IMPDH2), Truncated

Uniprot Id

P12268

Target Species

Human

Target Name

IMPDH2

Target Full Name

Inosine-5'-monophosphate dehydrogenase 2

Target Function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Target Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytosol.

Target Protein Families

IMPDH/GMPR family

Target Tissue Specificity

IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor.

Target Research Area

Cancer

Target Synonyms

IMDH2_HUMAN; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPD2 ; IMPDH 2; IMPDH II; IMPDH-II; Impdh2; Inosine 5' monophosphate dehydrogenase 2; Inosine 5' phosphate dehydrogenase 2; Inosine monophosphate dehydrogenase type II; Inosine-5''-monophosphate dehydrogenase 2

Target Background

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.