Recombinant Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (PPIP5K1), Truncated

Uniprot Id

Q6PFW1

Target Species

Human

Target Name

PPIP5K1

Target Full Name

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Target Function

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress

Target Subcellular Location

Cytoplasm, cytosol. Cell membrane.

Target Protein Families

Histidine acid phosphatase family, VIP1 subfamily

Target Tissue Specificity

Widely expressed, with a higher expression in skeletal muscle, heart and brain.

Target Synonyms

PPIP5K1; HISPPD2A; IP6K; IPS1; KIAA0377; VIP1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; EC 2.7.4.21; EC 2.7.4.24; Diphosphoinositol pentakisphosphate kinase 1; Histidine acid phosphatase domain-containing protein 2A; IP6 kinase; Inositol pyrophosphate synthase 1; InsP6 and PP-IP5 kinase 1; VIP1 homolog; hsVIP1