Recombinant Human Integrator complex subunit 7 (INTS7), Truncated

Uniprot Id

Q9NVH2

Target Species

Human

Target Name

INTS7

Target Full Name

Integrator complex subunit 7

Target Function

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex.

Target Subcellular Location

Nucleus. Chromosome. Cytoplasm. Note=Localizes to sites of DNA damage in a H2AX-independent manner.

Target Protein Families

Integrator subunit 7 family

Target Synonyms

INTS7; 5930412E23Rik; C1orf73; Chromosome 1 open reading frame 73 ; chunp6916; DKFZp434B168; FLJ10736; FLJ12447; Int7; INT7_HUMAN; Integrator complex subunit 7; Ints7; Ints7 integrator complex subunit 7; OTTHUMP00000035211 ; RGD1308014

Target Background

This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.