Recombinant Human Integrin alpha-7 (ITGA7), Truncated

Uniprot Id

Q13683

Target Species

Human

Target Name

ITGA7

Target Full Name

Integrin alpha-7

Target Function

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

Target Involvement

Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Integrin alpha chain family

Target Tissue Specificity

Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes

Target Synonyms

alpha 7; FLJ25220; Integrin alpha 7; Integrin alpha 7 chain; Integrin alpha 7 heavy chain; Integrin alpha 7 light chain; Integrin alpha-7 70 kDa form; ITA7_HUMAN; ITGA 7; Itga7

Target Background

The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.