Recombinant Human Interferon alpha-2 (IFNA2)

Uniprot Id

P01563

Target Species

Human

Target Name

IFNA2

Target Full Name

Interferon alpha-2

Target Function

Produced by macrophages, IFN-alpha have antiviral activities.

Target Subcellular Location

Secreted.

Target Protein Families

Alpha/beta interferon family

Target Research Area

Cancer

Target Synonyms

Alpha 2a interferon ; IFN alpha 2b; IFN-alpha-2; IFNA; Ifna2; IFNA2_HUMAN; INFA2; Interferon alpha 2; Interferon alpha A; Interferon alpha-2; Interferon alpha-A; LeIF A; LeIFA

Target Background

This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach.