Recombinant Human Interleukin-24 (IL24)

Uniprot Id

Q13007

Target Species

Human

Target Name

IL24

Target Full Name

Interleukin-24

Target Function

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Target Subcellular Location

Secreted.

Target Protein Families

IL-10 family

Target Tissue Specificity

Up-regulated in melanoma cells induced to terminally differentiate.

Target Synonyms

C49A; FISP; IL 24; IL 4 induced secreted protein; IL-24; IL10B; Il24; IL24_HUMAN; interleukin 24; Interleukin-24; MDA-7; MDA7; Melanocyte associated Mda 7; Melanoma differentiation association protein 7; Melanoma differentiation-associated gene 7 protein; Mob5; ST16; Suppression of tumorigenicity 16 (melanoma differentiation); Suppression of tumorigenicity 16; Suppression of tumorigenicity 16 protein

Target Background

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.