Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4), Truncated

Uniprot Id

O15554

Target Species

Human

Target Name

KCNN4

Target Full Name

Intermediate conductance calcium-activated potassium channel protein 4

Target Function

Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis.

Target Involvement

Dehydrated hereditary stomatocytosis 2 (DHS2)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel KCNN family, KCa3.1/KCNN4 subfamily

Target Tissue Specificity

Widely expressed in non-excitable tissues.

Target Synonyms

KCNN4; IK1; IKCA1; KCA4; SK4; Intermediate conductance calcium-activated potassium channel protein 4; SKCa 4; SKCa4; IKCa1; KCa3.1; KCa4; Putative Gardos channel

Target Background

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.