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Recombinant Human IQ motif and SEC7 domain-containing protein 1 (IQSEC1), Truncated

ACP16650

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Specifications

Cat.No	ACP16650	Target Name	IQSEC1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q6DN90

Background Information

Uniprot Id

Q6DN90
Target Species

Human
Target Name

IQSEC1
Target Full Name

IQ motif and SEC7 domain-containing protein 1
Target Function

Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin. Involved in neuronal development. In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors.
Target Subcellular Location

Cytoplasm. Nucleus. Cell junction, synapse, postsynaptic density. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=At steady state, may be preferentially cytosolic.
Target Protein Families

BRAG family
Target Tissue Specificity

Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.
Target Synonyms

IQSEC1; ARFGEP100; BRAG2; KIAA0763; IQ motif and SEC7 domain-containing protein 1; ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; Brefeldin-resistant Arf-GEF 2 protein; BRAG2

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Recombinant Human IQ motif and SEC7 domain-containing protein 1 (IQSEC1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human IQ motif and SEC7 domain-containing protein 1 (IQSEC1), Truncated Now

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