Recombinant Human Izumo sperm-egg fusion protein 1 (IZUMO1), Truncated

The region for expressing recombinant Human IZUMO1 contains amino acids 22-292. This IZUMO1 protein is theoretically predicted to have a molecular weight of 38.1 kDa. This protein is generated in a e.coli-based system. The IZUMO1 gene fragment has been modified by fusing the N-terminal 10xHis tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant IZUMO1 protein during the following stages.The human Izumo sperm-egg fusion protein 1 (IZUMO1) is a transmembrane protein found on the surface of sperm cells. It plays a crucial role in the process of fertilization by mediating the fusion between sperm and egg during gamete interaction. IZUMO1 is essential for establishing the initial contact between the sperm and the egg, leading to the formation of a fertilization pore and subsequent fusion of the two gametes' membranes. The molecular interactions involving IZUMO1 are part of the intricate and highly regulated mechanisms that govern the fusion event, ensuring successful fertilization. Understanding IZUMO1's function provides valuable insights into reproductive biology and potential avenues for contraceptive development.