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Recombinant Human Kelch repeat and BTB domain-containing protein 5 (KBTBD5)

ACP17605

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Specifications

Cat.No	ACP17605	Target Name	KLHL40
Target Synonyms	KBTB5_HUMAN; kbtbd5; Kelch repeat and BTB (POZ) domain containing 5; Kelch repeat and BTB domain-containing protein 5; Sarcosynapsin; SRYP	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-621
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q2TBA0

Background Information

Uniprot Id

Q2TBA0
Target Species

Human
Target Name

KLHL40
Target Full Name

Kelch-like protein 40
Target Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex. Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear.
Target Involvement

Nemaline myopathy 8 (NEM8)
Target Subcellular Location

Cytoplasm. Cytoplasm, myofibril, sarcomere, A band. Cytoplasm, myofibril, sarcomere, I band.
Target Protein Families

KLHL40 family
Target Tissue Specificity

Highly expressed in fetal (19, 23 and 31 weeks of gestation) and adult skeletal muscle; expression levels tend to be higher in fetal compared to postnatal muscles (at protein level). Also expressed in fetal and adult heart.
Target Synonyms

KBTB5_HUMAN; kbtbd5; Kelch repeat and BTB (POZ) domain containing 5; Kelch repeat and BTB domain-containing protein 5; Sarcosynapsin; SRYP

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Recombinant Human Kelch repeat and BTB domain-containing protein 5 (KBTBD5)

Specifications

Immunogen Information

Inquire Recombinant Human Kelch repeat and BTB domain-containing protein 5 (KBTBD5) Now

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