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| Cat.No | ACP15410 | Target Name | KBTBD6 |
|---|---|---|---|
| Target Synonyms | KBTB6_HUMAN; KBTBD6; Kelch repeat and BTB (POZ) domain containing 6; Kelch repeat and BTB domain-containing protein 6 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-674 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86V97 |
|---|
Uniprot Id
Q86V97
Target Species
Human
Target Name
KBTBD6
Target Full Name
Kelch repeat and BTB domain-containing protein 6
Target Function
As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Synonyms
KBTB6_HUMAN; KBTBD6; Kelch repeat and BTB (POZ) domain containing 6; Kelch repeat and BTB domain-containing protein 6
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