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| Cat.No | ACP10954 | Target Name | SPC25 |
|---|---|---|---|
| Target Synonyms | AD024; hSpc25; Kinetochore protein Spc25; SPBC25; SPC25; SPC25_HUMAN; spindle pole body component 25 homolog | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-224 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HBM1 |
|---|
Uniprot Id
Q9HBM1
Target Species
Human
Target Name
SPC25
Target Full Name
Kinetochore protein Spc25
Target Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Target Subcellular Location
Nucleus. Chromosome, centromere, kinetochore.
Target Protein Families
SPC25 family
Target Synonyms
AD024; hSpc25; Kinetochore protein Spc25; SPBC25; SPC25; SPC25_HUMAN; spindle pole body component 25 homolog
Target Background
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity.
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