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| Cat.No | ACP13126 | Target Name | LTBP4 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N2S1 |
|---|
Uniprot Id
Q8N2S1
Target Species
Human
Target Name
LTBP4
Target Full Name
Latent-transforming growth factor beta-binding protein 4
Target Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
Target Involvement
Urban-Rifkin-Davis syndrome (URDS); Duchenne muscular dystrophy (DMD)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
LTBP family
Target Tissue Specificity
Highly expressed in heart, skeletal muscle, pancreas, uterus, and small intestine. Weakly expressed in placenta and lung.
Target Synonyms
latent transforming growth factor beta binding protein 4; latent transforming growth factor beta binding protein 4L; Latent-transforming growth factor beta-binding protein 4; LTBP 4; LTBP-4; LTBP4; LTBP4_HUMAN; LTBP4L; LTBP4S
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