Recombinant Human Mannan-binding lectin serine protease 2 (MASP2)

Uniprot Id

O00187

Target Species

Human

Target Name

MASP2

Target Full Name

Mannan-binding lectin serine protease 2

Target Function

Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.

Target Involvement

MASP2 deficiency (MASPD)

Target Subcellular Location

Secreted.

Target Protein Families

Peptidase S1 family

Target Tissue Specificity

Plasma.

Target Research Area

Cardiovascular

Target Synonyms

MASP2Mannan-binding lectin serine protease 2; EC 3.4.21.104; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]

Target Background

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.