Recombinant Human MHC class II regulatory factor RFX1 (RFX1), Truncated

Uniprot Id

P22670

Target Species

Human

Target Name

RFX1

Target Full Name

MHC class II regulatory factor RFX1

Target Function

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.

Target Subcellular Location

Nucleus.

Target Protein Families

RFX family

Target Synonyms

AI047719; AI385641; EF-C; EFC; Enhancer factor C; MHC class II regulatory factor RFX; MHC class II regulatory factor RFX1; Regulatory factor X 1; Regulatory factor X, 1 (influences HLA class II expression); Regulatory factor X1 ; RFX; RFX-1; Rfx1; RFX1_HUMAN; Trans-acting regulatory factor 1; Transcription factor RFX1

Target Background

This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE).