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Amino acids 22-173 constitute the expression domain of recombinant Human MFAP5. This MFAP5 protein is theoretically predicted to have a molecular weight of 33.3 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 6xHis-SUMO tag into the MFAP5 encoding gene fragment was conducted, allowing for easier detection and purification of the MFAP5 protein in subsequent stages.Human Microfibrillar-Associated Protein 5 (MFAP5) is involved in extracellular matrix (ECM) organization, interacting with elastin and fibrillin to contribute to tissue elasticity and stability. In vascular biology, MFAP5 regulates elastic fiber assembly, impacting arterial compliance. Its role in tissue development and repair makes MFAP5 relevant in regenerative medicine and wound healing research. In cancer biology, MFAP5 is implicated in tumor progression and metastasis, potentially serving as a prognostic marker. Investigating MFAP5 provides insights into ECM dynamics, vascular physiology, and cancer microenvironment, offering potential applications in cardiovascular research, tissue engineering, and cancer therapeutics.
Amino acids 22-173 constitute the expression domain of recombinant Human MFAP5. This MFAP5 protein is theoretically predicted to have a molecular weight of 33.3 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 6xHis-SUMO tag into the MFAP5 encoding gene fragment was conducted, allowing for easier detection and purification of the MFAP5 protein in subsequent stages.Human Microfibrillar-Associated Protein 5 (MFAP5) is involved in extracellular matrix (ECM) organization, interacting with elastin and fibrillin to contribute to tissue elasticity and stability. In vascular biology, MFAP5 regulates elastic fiber assembly, impacting arterial compliance. Its role in tissue development and repair makes MFAP5 relevant in regenerative medicine and wound healing research. In cancer biology, MFAP5 is implicated in tumor progression and metastasis, potentially serving as a prognostic marker. Investigating MFAP5 provides insights into ECM dynamics, vascular physiology, and cancer microenvironment, offering potential applications in cardiovascular research, tissue engineering, and cancer therapeutics.
| Cat.No | ACP04063 | Target Name | MFAP5 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 22-173aa | Mol Weight | 33.3kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13361 |
|---|
Uniprot Id
Q13361
Target Species
Human
Target Name
MFAP5
Target Full Name
Microfibrillar-associated protein 5
Target Function
May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity. Component of the elastin-associated microfibrils.
Target Involvement
Aortic aneurysm, familial thoracic 9 (AAT9)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
MFAP family
Target Research Area
Cancer
Target Synonyms
AAT9; MAGP 2; MAGP-2; MAGP2; MFAP 5; MFAP-5; MFAP5; MFAP5_HUMAN; Microfibril associated glycoprotein 2; Microfibril-associated glycoprotein 2; microfibrillar associated protein 5; Microfibrillar associated protein 5 precursor ; Microfibrillar-associated protein 5; MP25
Target Background
This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms.
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