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Amino acids 1-126 constitute the expression domain of recombinant Human MAP1LC3C. The calculated molecular weight for this MAP1LC3C protein is 20.7 kDa. The MAP1LC3C protein was expressed in e.coli. The N-terminal 10xHis tag was fused into the coding gene segment of MAP1LC3C, making it easier to detect and purify the MAP1LC3C recombinant protein in the later stages of expression and purification.The human microtubule-associated protein 1A/1B light chain 3C (MAP1MAP1LC3C) is a member of the LC3 family and functions in the formation of autophagosomes, which are essential structures in autophagy, a cellular process responsible for degrading and recycling cellular components. MAP1LC3C undergoes lipidation, facilitating its association with autophagosomal membranes. Its involvement in autophagy allows for the targeted removal of damaged or obsolete cellular constituents. Research on MAP1LC3C focuses on understanding its precise role in autophagic processes, its regulation, and its implications in various physiological and pathological conditions, including neurodegenerative diseases and cancer.
Amino acids 1-126 constitute the expression domain of recombinant Human MAP1LC3C. The calculated molecular weight for this MAP1LC3C protein is 20.7 kDa. The MAP1LC3C protein was expressed in e.coli. The N-terminal 10xHis tag was fused into the coding gene segment of MAP1LC3C, making it easier to detect and purify the MAP1LC3C recombinant protein in the later stages of expression and purification.The human microtubule-associated protein 1A/1B light chain 3C (MAP1MAP1LC3C) is a member of the LC3 family and functions in the formation of autophagosomes, which are essential structures in autophagy, a cellular process responsible for degrading and recycling cellular components. MAP1LC3C undergoes lipidation, facilitating its association with autophagosomal membranes. Its involvement in autophagy allows for the targeted removal of damaged or obsolete cellular constituents. Research on MAP1LC3C focuses on understanding its precise role in autophagic processes, its regulation, and its implications in various physiological and pathological conditions, including neurodegenerative diseases and cancer.
| Cat.No | ACP05115 | Target Name | MAP1LC3C |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-126aa | Mol Weight | 20.7 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BXW4 |
|---|
Uniprot Id
Q9BXW4
Target Species
Human
Target Name
MAP1LC3C
Target Full Name
Microtubule-associated protein 1 light chain 3 gamma
Target Function
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.
Target Subcellular Location
Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.
Target Protein Families
ATG8 family
Target Tissue Specificity
Most abundant in placenta, lung and ovary.
Target Research Area
Cancer
Target Synonyms
ATG8J; Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; LC3 like protein 2; MAP1 light chain 3 like protein 2; MAP1 light chain 3 like protein 3; MAP1 light chain 3-like protein 3; MAP1A/MAP1B LC3 C; MAP1A/MAP1B light chain 3 C; MAP1LC3C; Microtubule-associated protein 1 light chain 3 gamma; Microtubule-associated proteins 1A/1B light chain 3C; MLP3C_HUMAN
Target Background
Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).
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