Recombinant Human Mitogen-activated protein kinase-binding protein 1 (MAPKBP1), Truncated

Uniprot Id

O60336

Target Species

Human

Target Name

MAPKBP1

Target Full Name

Mitogen-activated protein kinase-binding protein 1

Target Function

Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway.

Target Involvement

Nephronophthisis 20 (NPHP20)

Target Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole.

Target Tissue Specificity

Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes. Expressed in kidney.

Target Synonyms

JNK binding protein 1; JNK-binding protein 1; JNKBP-1; JNKBP1; KIAA0596; MABP1_HUMAN; MAPKBP 1; mapkbp1; Mitogen activated protein kinase binding protein 1; Mitogen-activated protein kinase-binding protein 1

Target Background

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.