Recombinant Human Mucolipin-2 (MCOLN2), Truncated

Uniprot Id

Q8IZK6

Target Species

Human

Target Name

MCOLN2

Target Full Name

Mucolipin-2

Target Function

Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Target Protein Families

Transient receptor (TC 1.A.4) family, Polycystin subfamily, MCOLN2 sub-subfamily

Target Synonyms

MCOLN2; Mucolipin-2; Transient receptor potential channel mucolipin 2; TRPML2