Recombinant Human Multidrug and toxin extrusion protein 1 (SLC47A1), Truncated

Uniprot Id

Q96FL8

Target Species

Human

Target Name

SLC47A1

Target Full Name

Multidrug and toxin extrusion protein 1

Target Function

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.

Target Protein Families

Multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Target Tissue Specificity

Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).

Target Synonyms

FLJ10847; hMATE-1; hMATE1; MATE-1; MATE1; MGC6482; multidrug and toxin extrusion 1; Multidrug and toxin extrusion protein 1; S47A1_HUMAN; SLC47A1; Solute carrier family 47 member 1

Target Background

This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function.