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| Cat.No | ACP21525 | Target Name | MSH4 |
|---|---|---|---|
| Target Synonyms | hMSH4; MSH 4; MSH4; MSH4_HUMAN; MutS homolog 4 (E. Coli); MutS homolog 4; MutS protein homolog 4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O15457 |
|---|
Uniprot Id
O15457
Target Species
Human
Target Name
MSH4
Target Full Name
MutS protein homolog 4
Target Function
Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
Target Subcellular Location
Chromosome.
Target Protein Families
DNA mismatch repair MutS family
Target Tissue Specificity
Testis and ovary specific.
Target Synonyms
hMSH4; MSH 4; MSH4; MSH4_HUMAN; MutS homolog 4 (E. Coli); MutS homolog 4; MutS protein homolog 4
Target Background
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.
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