Recombinant Human Myotubularin-related protein 3 (MTMR3), Truncated

Uniprot Id

Q13615

Target Species

Human

Target Name

MTMR3

Target Full Name

Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

Target Function

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues.

Target Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily

Target Synonyms

FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; MTMR3; MTMR3_HUMAN; Myotubularin-related protein 3; Zinc finger FYVE domain-containing protein 10

Target Background

This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3, 5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.