Home Products Recombinant Human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA), Truncated

Recombinant Human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA), Truncated

ACP18876

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Specifications

Cat.No	ACP18876	Target Name	NAGPA
Target Synonyms	Mannose 6-phosphate-uncovering enzyme; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; NAGPA; NAGPA_HUMAN; Phosphodiester alpha-GlcNAcase	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9UK23

Background Information

Uniprot Id

Q9UK23
Target Species

Human
Target Name

NAGPA
Target Full Name

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Target Function

Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases.
Target Involvement

Defects in NAGPA have been suggested to play a role in susceptibility to persistent stuttering. Stuttering is a common speech disorder characterized by repetitions, prolongations, and interruptions in the flow of speech.
Target Subcellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Note=Cis/medial Golgi.
Target Tissue Specificity

Isoform 2 may be brain-specific.
Target Synonyms

Mannose 6-phosphate-uncovering enzyme; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; NAGPA; NAGPA_HUMAN; Phosphodiester alpha-GlcNAcase

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Recombinant Human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA), Truncated Now

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