Recombinant Human NAD (P) transhydrogenase, mitochondrial (NNT), Truncated

Uniprot Id

Q13423

Target Species

Human

Target Name

NNT

Target Full Name

NAD(P) transhydrogenase, mitochondrial

Target Function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.

Target Involvement

Glucocorticoid deficiency 4 with or without mineralocorticoid deficiency (GCCD4)

Target Subcellular Location

Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.

Target Protein Families

AlaDH/PNT family; PNT beta subunit family

Target Tissue Specificity

Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.

Target Synonyms

GCCD4; mitochondrial; NAD(P) transhydrogenase; NAD(P) transhydrogenase mitochondrial; Nicotinamide nucleotide transhydrogenase; NNT; NNTM; NNTM_HUMAN; Pyridine nucleotide transhydrogenase

Target Background

This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification.