Recombinant Human NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (NDUFB3), Truncated

Uniprot Id

O43676

Target Species

Human

Target Name

NDUFB3

Target Full Name

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

Target Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Target Involvement

Mitochondrial complex I deficiency (MT-C1D)

Target Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Target Protein Families

Complex I NDUFB3 subunit family

Target Synonyms

NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; Complex I-B12; CI-B12; NADH-ubiquinone oxidoreductase B12 subunit

Target Background

This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene.