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The recombinant Human NRL was expressed with the amino acid range of 1-237. The expected molecular weight for the NRL protein is calculated to be 33.4 kDa. This NRL recombinant protein is manufactured in e.coli. The NRL coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant NRL protein in following stages of expression and purification.The human neural retina-specific leucine zipper protein (NRL) is a transcription factor that plays a crucial role in the development and maintenance of photoreceptor cells in the retina. NRL is predominantly expressed in rod photoreceptors and is involved in the regulation of genes associated with rod cell differentiation and function. It promotes the development of rod photoreceptors while suppressing the formation of cone photoreceptors. NRL is essential for the proper functioning of the visual system, as it contributes to the synthesis of visual pigments and the overall sensitivity of rod cells to light. Research areas related to NRL include retinal development, visual neuroscience, and potential implications for retinal diseases and therapies. Understanding NRL's role provides insights into the molecular mechanisms governing vision and may contribute to the development of treatments for retinal disorders.
The recombinant Human NRL was expressed with the amino acid range of 1-237. The expected molecular weight for the NRL protein is calculated to be 33.4 kDa. This NRL recombinant protein is manufactured in e.coli. The NRL coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant NRL protein in following stages of expression and purification.The human neural retina-specific leucine zipper protein (NRL) is a transcription factor that plays a crucial role in the development and maintenance of photoreceptor cells in the retina. NRL is predominantly expressed in rod photoreceptors and is involved in the regulation of genes associated with rod cell differentiation and function. It promotes the development of rod photoreceptors while suppressing the formation of cone photoreceptors. NRL is essential for the proper functioning of the visual system, as it contributes to the synthesis of visual pigments and the overall sensitivity of rod cells to light. Research areas related to NRL include retinal development, visual neuroscience, and potential implications for retinal diseases and therapies. Understanding NRL’s role provides insights into the molecular mechanisms governing vision and may contribute to the development of treatments for retinal disorders.
| Cat.No | ACP05233 | Target Name | NRL |
|---|---|---|---|
| Target Synonyms | D14S46E; Neural retina-specific leucine zipper protein; Neural retinal specific leucine zipper; NRL; NRL MAF; NRL_HUMAN; RP27 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-237aa |
| Mol Weight | 33.4 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P54845 |
|---|
Uniprot Id
P54845
Target Species
Human
Target Name
NRL
Target Full Name
Neural retina-specific leucine zipper protein
Target Function
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds in a sequence-specific manner to the rhodopsin promoter.
Target Involvement
Retinitis pigmentosa 27 (RP27); Retinal degeneration autosomal recessive clumped pigment type (RDCP)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
BZIP family
Target Tissue Specificity
Expressed in the brain and the retina. Expressed strongly in rod and cone cells (at protein level).
Target Research Area
Others
Target Synonyms
D14S46E; Neural retina-specific leucine zipper protein; Neural retinal specific leucine zipper; NRL; NRL MAF; NRL_HUMAN; RP27
Target Background
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases.
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