Recombinant Human Neurocalcin-delta (NCALD)

Uniprot Id

P61601

Target Species

Human

Target Name

NCALD

Target Full Name

Neurocalcin-delta

Target Function

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Target Protein Families

Recoverin family

Target Tissue Specificity

Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.

Target Research Area

Neuroscience

Target Synonyms

NCALD; Neurocalcin-delta

Target Background

This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined.