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| Cat.No | ACP04143 | Target Name | NET1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-542aa | Mol Weight | 77.9kDa |
| Protein Length | Full Length of Isoform 2 | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q7Z628 |
|---|
Uniprot Id
Q7Z628
Target Species
Human
Target Name
NET1
Target Full Name
Neuroepithelial cell-transforming gene 1 protein
Target Function
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Tissue Specificity
Widely expressed.
Target Research Area
Signal Transduction
Target Synonyms
ARHG8_HUMAN; ARHGEF8; GLYT2 ; Guanine nucleotide regulatory protein oncogene; MGC114559 ; MGC127767 ; MGC53602 ; mNET1; Net1; NET1A; Neuroepithelial cell transforming gene 1; Neuroepithelial cell-transforming gene 1 protein; p65 Net1 proto oncogene; Proto-oncogene p65 Net1; Rho guanine nucleotide exchange factor 8; Rho guanine nucleotide exchange factor GEF 8
Target Background
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
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