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| Cat.No | ACP13205 | Target Name | ZNF274 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-653 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96GC6 |
|---|
Uniprot Id
Q96GC6
Target Species
Human
Target Name
ZNF274
Target Full Name
Neurotrophin receptor-interacting factor homolog
Target Function
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
Target Subcellular Location
Cytoplasm. Nucleus, nucleolus.
Target Protein Families
Krueppel C2H2-type zinc-finger protein family
Target Synonyms
ZNF274; ZKSCAN19; SP2114Neurotrophin receptor-interacting factor homolog; Zinc finger protein 274; Zinc finger protein HFB101; Zinc finger protein with KRAB and SCAN domains 19; Zinc finger protein zfp2; Zf2
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