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Recombinant Human Nitrogen permease regulator 3-like protein (NPRL3)

ACP18087

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Specifications

Cat.No	ACP18087	Target Name	NPRL3
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-569	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q12980

Background Information

Uniprot Id

Q12980
Target Species

Human
Target Name

NPRL3
Target Full Name

GATOR1 complex protein NPRL3
Target Function

As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Target Involvement

Epilepsy, familial focal, with variable foci 3 (FFEVF3)
Target Subcellular Location

Lysosome membrane.
Target Protein Families

NPR3 family
Target Tissue Specificity

Widely expressed. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes.
Target Synonyms

4 gene protein; Alpha-globin regulatory element-containing gene protein; C16ORF35; CGTHBA; Conserved gene telomeric to alpha globin cluster; HS 40; MARE; Nitrogen permease regulator 3-like protein; Nitrogen permease regulator-like 3 (S. cerevisiae); NPR3; NPRL3; NPRL3_HUMAN; Protein CGTHBA; RMD11

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Recombinant Human Nitrogen permease regulator 3-like protein (NPRL3)

Specifications

Immunogen Information

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