Recombinant Human Non-structural maintenance of chromosomes element 3 homolog (NSMCE3)

Uniprot Id

Q96MG7

Target Species

Human

Target Name

NSMCE3

Target Full Name

Non-structural maintenance of chromosomes element 3 homolog

Target Function

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest.

Target Involvement

Lung disease, immunodeficiency, and chromosome breakage syndrome (LICS)

Target Subcellular Location

Cytoplasm. Nucleus. Chromosome, telomere.

Target Tissue Specificity

Ubiquitous.

Target Synonyms

NSMCE3; HCA4; MAGEG1; NDNL2; Non-structural maintenance of chromosomes element 3 homolog; Non-SMC element 3 homolog; Hepatocellular carcinoma-associated protein 4; MAGE-G1 antigen; Melanoma-associated antigen G1; Necdin-like protein 2