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| Cat.No | ACP10881 | Target Name | NSMCE4A |
|---|---|---|---|
| Target Synonyms | NSMCE4A; C10orf86; PP4762; Non-structural maintenance of chromosomes element 4 homolog A; NS4EA; Non-SMC element 4 homolog A | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-385 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NXX6 |
|---|
Uniprot Id
Q9NXX6
Target Species
Human
Target Name
NSMCE4A
Target Full Name
Non-structural maintenance of chromosomes element 4 homolog A
Target Function
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus
Target Subcellular Location
Nucleus. Chromosome, telomere.
Target Protein Families
NSE4 family
Target Synonyms
NSMCE4A; C10orf86; PP4762; Non-structural maintenance of chromosomes element 4 homolog A; NS4EA; Non-SMC element 4 homolog A
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