Recombinant Human Notch homolog 2 N-terminal-like protein (NOTCH2NL)

Uniprot Id

Q7Z3S9

Target Species

Human

Target Name

NOTCH2NLA

Target Full Name

Notch homolog 2 N-terminal-like protein A

Target Function

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation

Target Subcellular Location

Secreted. Cytoplasm.

Target Protein Families

NOTCH family

Target Tissue Specificity

Widely expressed with higher levels in leukocytes and lymph nodes. Expressed in radial glia neural stem cells during cortical development.

Target Synonyms

N2N; Notch 2 N terminal like; Notch homolog 2 (Drosophila) N-terminal like; Notch homolog 2 N-terminal-like protein; NOTCH2NL; NT2NL_HUMAN; OTTHUMP00000015593