Recombinant Human Nuclear factor 1 B-type (NFIB)

Uniprot Id

O00712

Target Species

Human

Target Name

NFIB

Target Full Name

Nuclear factor 1 B-type

Target Function

Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Target Subcellular Location

Nucleus.

Target Protein Families

CTF/NF-I family

Target Synonyms

CCAAT Box Binding Transcription Factor; CCAAT-box-binding transcription factor; CTF; HMGIC/NFIB; NF-I/B; NF1-B; NF1B; NF1B2; NFI-B; NFI-RED; Nfib; NFIB_HUMAN; NFIB2; NFIB3; Nuclear factor 1 B-type; Nuclear factor 1/B; Nuclear Factor 1B; Nuclear Factor I B; Nuclear factor I/B; TGGCA Binding Protein; TGGCA-binding protein; TRANSCRIPTION FACTOR NFIB

Target Background

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development; negative regulation of DNA binding activity; and regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm.