Recombinant Human Origin recognition complex subunit 1 (ORC1)

Cat.No	ACP01197	Target Name	ORC1
Target Synonyms	Replication control protein 1	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-861aa
Mol Weight	123.6 kDa	Protein Length	Full length
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01197

Target Name

ORC1

Target Synonyms

Replication control protein 1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-861aa

Mol Weight

123.6 kDa

Protein Length

Full length

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q13415

Background Information

Uniprot Id

Q13415
Target Species

Human
Target Name

ORC1
Target Full Name

Origin recognition complex subunit 1
Target Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Target Involvement

Meier-Gorlin syndrome 1 (MGORS1)
Target Subcellular Location

Nucleus.
Target Protein Families

ORC1 family
Target Research Area

Others
Target Synonyms

HSORC1; MmORC1; orc1; ORC1_HUMAN; ORC1L; Origin Recognition Complex 1; Origin recognition complex subunit 1 (yeast homolog) like; Origin recognition complex subunit 1; Origin recognition complex subunit 1 homolog; Origin recognition complex subunit 1 like (S. cerevisia; Origin recognition complex subunit 1 like; Origin recognition complex subunit 1 S. cerevisiae homolog like ; Origin recognition complex, subunit 1 like (yeast); PARC1; Replication control protein 1
Target Background

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Origin recognition complex subunit 1 (ORC1)

Specifications

Immunogen Information

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