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| Cat.No | ACP23319 | Target Name | CPOX |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 111-454 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P36551 |
|---|
Uniprot Id
P36551
Target Species
Human
Target Name
CPOX
Target Full Name
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Target Function
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
Target Involvement
Hereditary coproporphyria (HCP)
Target Subcellular Location
Mitochondrion intermembrane space.
Target Protein Families
Aerobic coproporphyrinogen-III oxidase family
Target Synonyms
Coprogen oxidase; COPROPORPHYRIA; Coproporphyrinogen III oxidase; Coproporphyrinogen Oxidase (CPOX); Coproporphyrinogen-III oxidase; Coproporphyrinogenase; COX; CPO; Cpox; CPX; HEM 6; Hem-6; Hem6; HEM6_HUMAN; mitochondrial
Target Background
The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).
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