Recombinant Human Oxysterol-binding protein-related protein 8 (OSBPL8), Truncated

Uniprot Id

Q9BZF1

Target Species

Human

Target Name

OSBPL8

Target Full Name

Oxysterol-binding protein-related protein 8

Target Function

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol.

Target Subcellular Location

[Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane.; [Isoform 3]: Endoplasmic reticulum membrane; Single-pass membrane protein.

Target Protein Families

OSBP family

Target Tissue Specificity

Widely expressed. Expressed at higher level in macrophages.

Target Synonyms

OSBPL8; KIAA1451; ORP8; OSBP10; Oxysterol-binding protein-related protein 8; ORP-8; OSBP-related protein 8

Target Background

This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants.