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Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM)

ACP16351

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Specifications

Cat.No	ACP16351	Target Name	NOTUM
Target Synonyms	NOTUM; notum pectinacetylesterase homolog (Drosophila) ; Notum pectinacetylesterase homolog; NOTUM_HUMAN; Protein notum homolog	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	20-496
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q6P988

Background Information

Uniprot Id

Q6P988
Target Species

Human
Target Name

NOTUM
Target Full Name

Palmitoleoyl-protein carboxylesterase NOTUM
Target Function

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
Target Subcellular Location

Secreted.
Target Protein Families

Pectinacetylesterase family, Notum subfamily
Target Tissue Specificity

Rarely expressed in adult normal tissues.
Target Research Area

Neuroscience
Target Synonyms

NOTUM; notum pectinacetylesterase homolog (Drosophila) ; Notum pectinacetylesterase homolog; NOTUM_HUMAN; Protein notum homolog
Target Background

Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region.

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Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM)

Specifications

Immunogen Information

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