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| Cat.No | ACP12770 | Target Name | PDZD8 |
|---|---|---|---|
| Target Synonyms | PDZD8; PDZK8; PDZ domain-containing protein 8; Sarcoma antigen NY-SAR-84/NY-SAR-104 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NEN9 |
|---|
Uniprot Id
Q8NEN9
Target Species
Human
Target Name
PDZD8
Target Full Name
PDZ domain-containing protein 8
Target Function
Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer. In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons. Plays an indirect role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplex virus 1 infection at an early stage.
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein.
Target Synonyms
PDZD8; PDZK8; PDZ domain-containing protein 8; Sarcoma antigen NY-SAR-84/NY-SAR-104
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