Recombinant Human Phosphofurin acidic cluster sorting protein 1 (PACS1), Truncated

Uniprot Id

Q6VY07

Target Species

Human

Target Name

PACS1

Target Full Name

Phosphofurin acidic cluster sorting protein 1

Target Function

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.

Target Involvement

Schuurs-Hoeijmakers syndrome (SHMS)

Target Subcellular Location

Golgi apparatus, trans-Golgi network.

Target Protein Families

PACS family

Target Synonyms

Cytosolic sorting protein PACS1; PACS 1; PACS-1; Pacs1; PACS1_HUMAN; Phosphofurin acidic cluster sorting protein 1

Target Background

This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.