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This Human PFAS recombinant protein was produced in E.coli, where the gene sequence encoding Human PFAS (1064-1302aa) was expressed with the N-terminal 10xHis-SUMO tag and C-terminal Myc tag. The purity of this PFAS protein was greater than 85% by SDS-PAGE.PFAS is part of the purine biosynthesis pathway, and its specific role in this pathway is to convert multiple substrates into 5-phosphoribosylformylglycinamidine (FGAR). This reaction is a critical step in purine synthesis. Purines are essential components of DNA and RNA and serve as precursors to important energy molecules like ATP and GTP within cells. PFAS's involvement in purine synthesis ensures that cells can manufacture an adequate supply of purines to support their survival and growth. The activity of PFAS is regulated by various factors, including substrate concentrations, feedback inhibition, and the actions of regulatory proteins. This precise regulation helps maintain the balance of the purine biosynthesis pathway.
This Human PFAS recombinant protein was produced in E.coli, where the gene sequence encoding Human PFAS (1064-1302aa) was expressed with the N-terminal 10xHis-SUMO tag and C-terminal Myc tag. The purity of this PFAS protein was greater than 85% by SDS-PAGE.PFAS is part of the purine biosynthesis pathway, and its specific role in this pathway is to convert multiple substrates into 5-phosphoribosylformylglycinamidine (FGAR). This reaction is a critical step in purine synthesis. Purines are essential components of DNA and RNA and serve as precursors to important energy molecules like ATP and GTP within cells. PFAS’s involvement in purine synthesis ensures that cells can manufacture an adequate supply of purines to support their survival and growth. The activity of PFAS is regulated by various factors, including substrate concentrations, feedback inhibition, and the actions of regulatory proteins. This precise regulation helps maintain the balance of the purine biosynthesis pathway.
| Cat.No | ACP02412 | Target Name | PFAS |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1064-1302aa | Mol Weight | 45.4 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O15067 |
|---|
Uniprot Id
O15067
Target Species
Human
Target Name
PFAS
Target Full Name
Phosphoribosylformylglycinamidine synthase
Target Function
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
Target Subcellular Location
Cytoplasm.
Target Protein Families
FGAMS family
Target Synonyms
PFAS; KIAA0361; Phosphoribosylformylglycinamidine synthase; FGAM synthase; FGAMS; EC 6.3.5.3; Formylglycinamide ribonucleotide amidotransferase; FGAR amidotransferase; FGAR-AT; Formylglycinamide ribotide amidotransferase
Target Background
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis.
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