Recombinant Human Phosphorylated adapter RNA export protein (PHAX)

Uniprot Id

Q9H814

Target Species

Human

Target Name

PHAX

Target Full Name

Phosphorylated adapter RNA export protein

Target Function

A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

Target Subcellular Location

Nucleus, nucleoplasm. Nucleus, Cajal body. Cytoplasm.

Target Protein Families

PHAX family

Target Synonyms

FLJ13193; PHAX; PHAX_HUMAN; Phosphorylated adapter RNA export protein; Phosphorylated adaptor for RNA export; RNA U small nuclear RNA export adapter protein; RNA U; small nuclear RNA export adapter (phosphorylation regulated); RNUXA