Recombinant Human Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1), Truncated

Uniprot Id

P41586

Target Species

Human

Target Name

ADCYAP1R1

Target Full Name

Pituitary adenylate cyclase-activating polypeptide type I receptor

Target Function

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 2 family

Target Tissue Specificity

Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

Target Synonyms

ADCYAP1R1; Pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP type I receptor; PACAP-R-1; PACAP-R1

Target Background

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.