Recombinant Human Piwi-like protein 3 (PIWIL3), Truncated

Uniprot Id

Q7Z3Z3

Target Species

Human

Target Name

PIWIL3

Target Full Name

Piwi-like protein 3

Target Function

May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Argonaute family, Piwi subfamily

Target Tissue Specificity

Expressed in testis.

Target Synonyms

HIWI3; Piwi like 3; Piwi-like protein 3; piwi-like RNA-mediated gene silencing 3; PIWIL3; PIWL3_HUMAN

Target Background

This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene.