Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
Expressing the recombinant Human PLXNA1 protein in e.coli cells involves inserting a DNA fragment encoding the Human PLXNA1 protein (986-1152aa) into a plasmid vector and transferring it to the e.coli cells. Positive cells are screened, cultured, and induced to express the PLXNA1 protein. The protein carries a N-terminal 6xHis tag. The cells are lysed to collect the recombinant Human PLXNA1 protein, which is purified through affinity purification and then identified using SDS-PAGE and subsequent staining of the gel with Coomassie Brilliant Blue. The purity of the resulting recombinant Human PLXNA1 protein exceeds 90%.
Expressing the recombinant Human PLXNA1 protein in e.coli cells involves inserting a DNA fragment encoding the Human PLXNA1 protein (986-1152aa) into a plasmid vector and transferring it to the e.coli cells. Positive cells are screened, cultured, and induced to express the PLXNA1 protein. The protein carries a N-terminal 6xHis tag. The cells are lysed to collect the recombinant Human PLXNA1 protein, which is purified through affinity purification and then identified using SDS-PAGE and subsequent staining of the gel with Coomassie Brilliant Blue. The purity of the resulting recombinant Human PLXNA1 protein exceeds 90%.
| Cat.No | ACP05079 | Target Name | PLXNA1 |
|---|---|---|---|
| Target Synonyms | PLXNA1; NOV; PLXN1; Plexin-A1; Semaphorin receptor NOV | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 986-1152aa |
| Mol Weight | 22.3kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UIW2 |
|---|
Uniprot Id
Q9UIW2
Target Species
Human
Target Name
PLXNA1
Target Full Name
Plexin-A1
Target Function
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Plexin family
Target Tissue Specificity
Detected in fetal brain, lung, liver and kidney.
Target Research Area
Neuroscience
Target Synonyms
PLXNA1; NOV; PLXN1; Plexin-A1; Semaphorin receptor NOV
Target Background
Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including generation of neurons; regulation of GTPase activity; and regulation of cell shape. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in cytosol and nucleoplasm.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
