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| Cat.No | ACP05939 | Target Name | PKD1L1 |
|---|---|---|---|
| Target Synonyms | PKD1L1; UNQ5785/PRO19563; Polycystic kidney disease protein 1-like 1; PC1-like 1 protein; Polycystin-1L1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8TDX9 |
|---|
Uniprot Id
Q8TDX9
Target Species
Human
Target Name
PKD1L1
Target Full Name
Polycystin-1-like protein 1
Target Function
Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.
Target Involvement
Heterotaxy, visceral, 8, autosomal (HTX8)
Target Subcellular Location
Cell projection, cilium membrane; Multi-pass membrane protein.
Target Protein Families
Polycystin family
Target Tissue Specificity
Detected in testis and in fetal and adult heart.
Target Synonyms
PKD1L1; UNQ5785/PRO19563; Polycystic kidney disease protein 1-like 1; PC1-like 1 protein; Polycystin-1L1
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