Recombinant Human Potassium voltage-gated channel subfamily A member 10 (KCNA10), Truncated

Uniprot Id

Q16322

Target Species

Human

Target Name

KCNA10

Target Full Name

Potassium voltage-gated channel subfamily A member 10

Target Function

Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.8/KCNA10 sub-subfamily

Target Tissue Specificity

Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells.

Target Synonyms

KCNA10; Potassium voltage-gated channel subfamily A member 10; Voltage-gated potassium channel subunit Kv1.8

Target Background

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.