Recombinant Human Potassium voltage-gated channel subfamily G member 4 (KCNG4), Truncated

Uniprot Id

Q8TDN1

Target Species

Human

Target Name

KCNG4

Target Full Name

Voltage-gated potassium channel regulatory subunit KCNG4

Target Function

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel family, G (TC 1.A.1.2) subfamily, Kv6.4/KCNG4 sub-subfamily

Target Tissue Specificity

Highly expressed in brain, and at lower levels in liver, small intestine and colon.

Target Synonyms

KCNG4; KCNG3; Potassium voltage-gated channel subfamily G member 4; Voltage-gated potassium channel subunit Kv6.4

Target Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues.