Recombinant Human Presenilins-associated rhomboid-like protein, mitochondrial (PARL), Truncated

Uniprot Id

Q9H300

Target Species

Human

Target Name

PARL

Target Full Name

Presenilin-associated rhomboid-like protein, mitochondrial

Target Function

Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.

Target Subcellular Location

Mitochondrion inner membrane; Multi-pass membrane protein.; [P-beta]: Nucleus.

Target Protein Families

Peptidase S54 family

Target Synonyms

PARL; PSARL; PRO2207; Presenilins-associated rhomboid-like protein, mitochondrial; Mitochondrial intramembrane cleaving protease PARL

Target Background

This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease.